Answer
Coma and increased plasma GHB concentrations have been reported with concomitant sodium oxybate and topiramate use, so possible pharmacodynamic and pharmacokinetic interactions cannot be excluded.
Sources for this answer
- Xyrem 500 mg/ml oral solutionUCB Pharma Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 24Document updated
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