Answer
Co-administration of valproate (1,250 mg/day) with sodium oxybate (6 g/day) increased sodium oxybate systemic exposure by approximately 25%, without significantly changing Cmax, and caused greater sleepiness and cognitive impairment than either drug alone.
Sources for this answer
- Xyrem 500 mg/ml oral solutionUCB Pharma Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 24Document updated
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