Answer
Propranolol with bupivacaine with adrenaline may cause severe hypertension and reflex bradycardia through alpha-mediated vasoconstriction, and may antagonise adrenaline’s cardiac and bronchodilator effects.
Sources for this answer
- Bupivacaine and Adrenaline (Epinephrine) Injection 0.5% w/v, 1 in 200,000ADVANZ Pharma · emc · SmPC §4.5 Interaction with other medicinal products · Version 11Document updated
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