Answer
Combining tapentadol phosphate with benzodiazepines may cause sedation, respiratory depression, coma and death, so combined prescribing should be reserved for patients without possible alternative treatments, considering dose reduction and the shortest possible treatment duration.
Sources for this answer
- Tapimio 50 mg prolonged-release capsulesNeuraxpharm UK Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 1Document updated
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