Answer
Fluconazole may increase systemic exposure to tapentadol phosphate by strongly inhibiting UGT enzymes involved in its major elimination pathway, conjugation with glucuronic acid.
Sources for this answer
- Tapimio 50 mg prolonged-release capsulesNeuraxpharm UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
Sources checked