Answer
Combining midazolam with opioids may cause sedation, respiratory depression, coma and death; this combination should be reserved for patients without alternative treatment options, using the lowest effective dose for the shortest possible duration and closely monitoring for sedation and respiratory depression.
Sources for this answer
- Midazolam 5mg in 1ml InjectionADVANZ Pharma · emc · SmPC §4.4 Special warnings and precautions for use · Version 9Document updated
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