Answer
In atorvastatin + ezetimibe, atorvastatin’s mean plasma elimination half-life is approximately 14 hours, ezetimibe and ezetimibe-glucuronide each have a half-life of approximately 22 hours, and HMG-CoA reductase inhibitory activity has a half-life of approximately 20–30 hours due to active metabolites.
Sources for this answer
- Ezetimibe/Atorvastatin 10 mg/10 mg Film-coated TabletRoma Pharmaceuticals Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 1Document updated
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