Answer
With atorvastatin + ezetimibe tablets, concomitant cholestyramine decreases the mean total ezetimibe (ezetimibe plus ezetimibe glucuronide) exposure (AUC) by approximately 55%, potentially lessening the additional LDL-cholesterol reduction.
Sources for this answer
- Ezetimibe/Atorvastatin 10 mg/10 mg Film-coated TabletRoma Pharmaceuticals Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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