What is the current first-line eradication therapy for H. pylori in the UK, and how long should it be administered?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

The current first-line eradication therapy for Helicobacter pylori infection in the UK is a 7-day, twice-daily course of a proton pump inhibitor (PPI) combined with amoxicillin and either clarithromycin or metronidazole .

The recommended duration of treatment is 7 days .

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