What are the first-line topical treatments for mild to moderate acne vulgaris in adolescents?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 14 August 2025Updated: 14 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Offer a 12-week course of one of the following first-line topical treatments for mild to moderate acne in adolescents:

  • A fixed combination of topical adapalene with topical benzoyl peroxide, applied once daily in the evening .
  • A fixed combination of topical tretinoin with topical clindamycin, applied once daily in the evening .
  • A fixed combination of topical benzoyl peroxide with topical clindamycin, applied once daily in the evening .

Consider topical benzoyl peroxide as monotherapy as an alternative if these options are contraindicated or the person wishes to avoid using a topical retinoid or an antibiotic .

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