skip to main content

Strongly suspected bacterial meningitis with a new focal neurological deficit — MRCEM SBA MCQ

Instant feedback + full explanation. One question, done properly.

HardResuscitation and critical illnessStrongly suspected bacterial meningitis with a new focal neurological deficitMRCEM SBA

A 38-year-old woman presents to the emergency department with fever, severe headache and neck stiffness. She is confused but maintaining her airway; her GCS is 14, blood pressure is 116/72 mmHg and capillary glucose is 6.1 mmol/L. During assessment she develops new right arm weakness. She has no rash or known antibiotic allergy. Blood sampling, intravenous access and monitoring can be established immediately. Which investigation and treatment sequence is most appropriate?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Take blood cultures, give intravenous ceftriaxone and dexamethasone, perform CT head after stabilisation, then perform lumbar puncture once the weakness resolves.

Fever, headache, neck stiffness and confusion make bacterial meningitis strongly suspected. Her new focal weakness changes the usual investigation sequence: neuroimaging is indicated, and lumbar puncture must not be performed while that feature persists. Take blood samples, start intravenous ceftriaxone promptly and give intravenous dexamethasone with or before the first antibiotic dose if possible. Stabilise her before CT; reassess whether lumbar puncture is safe once the focal feature has resolved. Arrange senior, infection-specialist and appropriate inpatient assessment. ([nice.org.uk](https://www.nice.org.uk/guidance/ng240/chapter/Recommendations)) A correctly recognises the need for CT but delays treatment until after imaging. B applies the usual preference for pre-antibiotic lumbar puncture despite a current contraindicating feature. C correctly treats before imaging, but a CT showing no mass lesion does not, by itself, remove the requirement to wait for the focal sign to resolve. E delays dexamethasone until microbiological confirmation, although it is indicated when bacterial meningitis is strongly suspected; antibiotics should not, however, be delayed if dexamethasone is unavailable. ([nice.org.uk](https://www.nice.org.uk/guidance/ng240/chapter/Recommendations))

Reference: NICE NG240: Meningitis (bacterial) and meningococcal disease — recommendations (19 March 2024) — https://www.nice.org.uk/guidance/ng240/chapter/recommendations NICE NG240: Antibiotics and corticosteroids for bacterial meningitis (19 March 2024) — https://www.nice.org.uk/guidance/ng240/chapter/Recommendations