Large-vessel occlusion stroke on DOAC — SCE Geriatric Medicine MCQ

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HardStroke careLarge-vessel occlusion stroke on DOACSCE Geriatric Medicine

An 83-year-old woman with non-valvular atrial fibrillation weighs 58 kg and has serum creatinine 142 micromol/L. If apixaban is selected, which dose is appropriate?

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Correct answer: E — 2.5 mg twice daily

For stroke prevention in non-valvular atrial fibrillation, apixaban is reduced to 2.5 mg twice daily when at least two of three criteria are present: age at least 80 years, body weight 60 kg or less, and serum creatinine at least 133 micromol/L. This patient meets all three. Renal function should be estimated with Cockcroft–Gault creatinine clearance for DOAC decisions.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/older-people