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Addisonian crisis — SCE Acute Medicine MCQ

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EasyAcute Renal and Metabolic EmergenciesAddisonian crisisSCE Acute Medicine

A 45-year-old woman with Addison's disease presents with diarrhoea, fever and collapse. BP is 78/42 mmHg, sodium 122 mmol/L, potassium 6.2 mmol/L and glucose 3.0 mmol/L. Her partner says she has been unable to keep tablets down for 24 hours. What is the most appropriate immediate action?

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Correct answer: EGive intravenous hydrocortisone and isotonic saline immediately

This is adrenal crisis, and hydrocortisone plus rapid isotonic saline should be given immediately without waiting for cortisol confirmation. Oral mineralocorticoid is inadequate in shock and vomiting. Hyperkalaemia may improve with steroid and fluid resuscitation but should be treated if there are ECG changes. Hyponatraemia here reflects cortisol and aldosterone deficiency with volume depletion, not a reason for fluid restriction.

Reference: Society for Endocrinology adrenal crisis guidance, BNF