A 43-year-old woman develops profuse watery diarrhoea seven days after clindamycin for dental infection. She is febrile, WCC 24 x 10^9/L, creatinine

Question

A 43-year-old woman develops profuse watery diarrhoea seven days after clindamycin for dental infection. She is febrile, WCC 24 x 10^9/L, creatinine 168 micromol/L and albumin 24 g/L. CT shows pancolitis without perforation. What is the most appropriate next step in management?

Accepted Answer

Give oral vancomycin with enteric isolation

Answer

Give oral vancomycin with intravenous metronidazole

Answer

Give oral metronidazole with enteric isolation

Answer

Give oral vancomycin with early surgical assessment

Answer

Give oral fidaxomicin with enteric isolation

Severe Clostridioides difficile colitis — SCE Acute Medicine MCQ

A 43-year-old woman develops profuse watery diarrhoea seven days after clindamycin for dental infection. She is febrile, WCC 24 x 10^9/L, creatinine 168 micromol/L and albumin 24 g/L. CT shows pancolitis without perforation. What is the most appropriate next step in management?