Primary adrenal insufficiency — RCPSC IM MCQ
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Correct answer: E — Give parenteral hydrocortisone with isotonic saline
The best answer is “Give parenteral hydrocortisone with isotonic saline”. This is primary adrenal crisis with shock and electrolyte disturbance. Hydrocortisone and isotonic fluid are lifesaving and must not await dynamic testing; mineralocorticoid alone is inadequate, fluid restriction worsens hypovolemia and thyroid hormone before steroid replacement can intensify crisis.
Reference: Emergency Care BC, adrenal crisis clinical summary: https://emergencycarebc.ca/wp-content/uploads/2022/06/Adrenal-Crisis-sept2020-v2-Summary.pdf