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Primary adrenal insufficiency — RCPSC IM MCQ

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HardEndocrinologyPrimary adrenal insufficiencyRCPSC IM

A 55-year-old has vomiting, hyperpigmentation, sodium 124 mmol/L, potassium 5.9 mmol/L, glucose 3.2 mmol/L and blood pressure 82/46 mmHg. Morning cortisol is very low and ACTH is markedly elevated. What treatment should begin immediately?

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Correct answer: EGive parenteral hydrocortisone with isotonic saline

The best answer is “Give parenteral hydrocortisone with isotonic saline”. This is primary adrenal crisis with shock and electrolyte disturbance. Hydrocortisone and isotonic fluid are lifesaving and must not await dynamic testing; mineralocorticoid alone is inadequate, fluid restriction worsens hypovolemia and thyroid hormone before steroid replacement can intensify crisis.

Reference: Emergency Care BC, adrenal crisis clinical summary: https://emergencycarebc.ca/wp-content/uploads/2022/06/Adrenal-Crisis-sept2020-v2-Summary.pdf