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Domperidone QT risk — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsDomperidone QT riskGPhC CRA

A 69-year-old woman asks to buy domperidone for nausea. She takes citalopram 20mg daily and amiodarone 200mg daily, and her discharge summary notes previous QT prolongation. Her nausea started after a new antibiotic yesterday. What is the most appropriate action?

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Correct answer: CAvoid domperidone and refer for prescriber assessment

Domperidone is associated with QT prolongation and serious cardiac arrhythmia risk, especially in older patients and with QT-prolonging medicines. This patient has multiple risk factors and needs prescriber assessment. Substituting another antiemetic without considering the cause and interactions may be unsafe. Increasing citalopram is not an antiemetic strategy.

Reference: BNF Domperidone; MHRA Drug Safety Update