DMARD infection advice — GPhC CRA MCQ
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Correct answer: B — Withhold methotrexate and adalimumab; arrange urgent infection assessment
The patient may have a serious infection and is immunosuppressed. Urgent clinical assessment is required, with further methotrexate and adalimumab doses withheld until the treating team advises restart. Continuing either immunosuppressant or delaying assessment is unsafe; trimethoprim also interacts dangerously with methotrexate.
Reference: BNF: methotrexate: https://bnf.nice.org.uk/drugs/methotrexate/