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Clozapine myocarditis signal — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyClozapine myocarditis signalGPhC CRA

A 26-year-old man started clozapine 3 weeks ago. His carer reports chest pain, shortness of breath, fever and unusual fatigue. The latest clozapine blood count was acceptable, and he also takes sodium valproate. What is the most appropriate action?

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Correct answer: A — Arrange urgent medical assessment for possible clozapine-related myocarditis

Clozapine can rarely cause myocarditis, particularly early in treatment. Chest pain, shortness of breath, fever and fatigue require urgent medical assessment even if neutrophil monitoring is acceptable. Blood count monitoring does not rule out myocarditis. Delaying review could be dangerous.

Reference: BNF Clozapine; MHRA safety advice