skip to main content

Morphine in renal impairment — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardRenal and Hepatic ImpairmentMorphine in renal impairmentGPhC CRA

A patient with eGFR 18 mL/min/1.73 m² is about to start oral baclofen for spasticity. Which proposed plan best reflects renal safety?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Review the need; if used, start about 5 mg daily with close monitoring

Baclofen is predominantly eliminated unchanged in urine. In renal impairment, product information advises a particularly low dose of about 5 mg daily, with close monitoring because encephalopathy has occurred at low doses. The prescriber should reassess the need and alternatives before treatment.

Reference: BNF: baclofen: https://bnf.nice.org.uk/drugs/baclofen/