skip to main content

Aciclovir renal dose and hydration — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateRenal and Hepatic ImpairmentAciclovir renal dose and hydrationGPhC CRA

A 74-year-old man with shingles is prescribed aciclovir 800mg five times daily. His eGFR is 29mL/min/1.73m2 and he takes bendroflumethiazide. He asks whether he can take the tablets with very little fluid overnight. What monitoring is required?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Renal function review to confirm dose suitability

Aciclovir requires renal dose consideration, and adequate hydration reduces crystalluria and renal toxicity risk. Older age, diuretic use and eGFR 29mL/min/1.73m2 make renal review important before confirming the regimen. INR, HbA1c and peak flow are not the relevant safety monitoring. The pharmacist should contact the prescriber and counsel on hydration.

Reference: BNF Aciclovir; NICE CKS Shingles