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Hypertension with type 2 diabetes — GPhC CRA MCQ

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HardCardiovascular TherapeuticsHypertension with type 2 diabetesGPhC CRA

A 58-year-old with type 2 diabetes has repeated urine ACR values of 18 and 21 mg/mmol, eGFR 72 mL/min/1.73 m² and BP 142/86 mmHg. They take amlodipine 10 mg daily. Which change best addresses renal and BP risk?

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Reveal the answer and explanation

Correct answer: BStart an ACE inhibitor or ARB, titrating with renal and potassium monitoring

Diabetes plus confirmed ACR at least 3 mg/mmol meets NICE criteria for an ACE inhibitor or ARB, titrated to the highest tolerated licensed dose. Renal function and potassium must be checked around initiation and titration. A diuretic or beta-blocker does not provide the same albuminuria-directed renoprotection; spironolactone needs a different indication and monitoring; dual renin–angiotensin-system blockade is unsafe.

Reference: NICE NG203: https://www.nice.org.uk/guidance/ng203/chapter/recommendations