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Gabapentin renal dose adjustment — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentGabapentin renal dose adjustmentGPhC CRA

A 77-year-old woman is prescribed gabapentin 300mg three times daily for neuropathic pain. Her eGFR is 24mL/min/1.73m2 and she has had two falls this week with new drowsiness. What is the most appropriate action?

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Correct answer: C — Query the dose because gabapentin requires renal adjustment and can increase falls risk

Gabapentin is renally cleared and dose reduction is needed in renal impairment. Drowsiness and falls suggest adverse effects that may be dose-related. The prescription should be reviewed before further supply. Pregabalin also requires renal adjustment and should not be substituted at the same milligram dose.

Reference: BNF