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Domperidone QT risk — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsDomperidone QT riskGPhC CRA

A patient taking erythromycin 500mg four times daily presents with nausea and palpitations. He also takes domperidone for gastroparesis and has potassium 3.1mmol/L. What is the most appropriate action?

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Correct answer: E — Refer urgently and contact the prescriber because additive QT risk is high

Erythromycin and domperidone both prolong the QT interval, and hypokalaemia increases arrhythmia risk. Palpitations in this setting require urgent assessment and prescriber review. Increasing domperidone would increase risk. Symptomatic treatment would not address a potentially serious rhythm problem.

Reference: BNF; MHRA Drug Safety Update