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H. pylori regimen interactions — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsH. pylori regimen interactionsGPhC CRA

A 61-year-old man with H. pylori eradication therapy is prescribed clarithromycin, amoxicillin and lansoprazole. He takes simvastatin 40mg nightly and colchicine 500micrograms twice daily. What is the most appropriate action?

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Correct answer: C — Contact the prescriber because clarithromycin interacts with both simvastatin and colchicine

Clarithromycin is a strong CYP3A4/P-glycoprotein inhibitor and can substantially increase simvastatin and colchicine exposure. The combination raises risks of myopathy, rhabdomyolysis and colchicine toxicity, particularly in older patients. Prescriber review is needed to adjust therapy or choose alternatives. Timing changes do not meaningfully prevent these interactions.

Reference: BNF