skip to main content

SGLT2 inhibitor perioperative advice — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardEndocrine TherapeuticsSGLT2 inhibitor perioperative adviceGPhC CRA

A 74-year-old man with type 2 diabetes is prescribed empagliflozin. His eGFR has declined to 25mL/min/1.73m2 and he is scheduled for bowel surgery next week. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Refer to the prescriber for perioperative withholding and renal suitability review

SGLT2 inhibitors are usually withheld around major surgery or acute illness because of ketoacidosis risk. Reduced eGFR may also affect appropriateness depending on indication and current guidance. The prescriber or perioperative team should review timing and diabetes management. Dose doubling and dehydration advice would increase harm risk.

Reference: BNF; MHRA Drug Safety Update