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Warfarin and amiodarone monitoring — GPhC CRA MCQ

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HardCardiovascular TherapeuticsWarfarin and amiodarone monitoringGPhC CRA

A patient collects warfarin 3mg tablets after a dose change. He has also been prescribed amiodarone 200mg daily for AF. His next anticoagulation clinic appointment is in 4 weeks. What monitoring is required?

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Correct answer: B — Arrange earlier INR monitoring because amiodarone can increase warfarin effect

Amiodarone can increase warfarin anticoagulant effect, and the interaction may develop over days to weeks because of amiodarone's long half-life. Earlier INR monitoring and anticoagulation clinic involvement are needed. A routine 4-week delay may expose the patient to bleeding risk. The other tests do not monitor the key interaction.

Reference: BNF