skip to main content

SGLT2 inhibitor ketoacidosis — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardEndocrine TherapeuticsSGLT2 inhibitor ketoacidosisGPhC CRA

A 55-year-old woman with type 2 diabetes starts dapagliflozin. She presents 2 weeks later with abdominal pain, vomiting and deep breathing. Capillary glucose is 11.8mmol/L and ketones are 4.2mmol/L. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Arrange emergency assessment for suspected euglycaemic ketoacidosis

SGLT2 inhibitors can cause diabetic ketoacidosis with glucose levels that are not markedly elevated. Vomiting, abdominal pain, deep breathing and high ketones require emergency assessment. Extra dapagliflozin would worsen risk and should not be advised. Symptomatic treatment would delay management of a potentially life-threatening adverse reaction.

Reference: BNF; MHRA Drug Safety Update