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Enoxaparin renal impairment — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentEnoxaparin renal impairmentGPhC CRA

A hospital discharge prescription includes enoxaparin 80mg twice daily for 7 days. The patient weighs 82kg but has eGFR 22mL/min/1.73m2 and platelets 88 x10^9/L. What is the most appropriate action?

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Correct answer: D — Query the dose and safety before supply because renal impairment and thrombocytopenia increase risk

Low molecular weight heparins are renally cleared and can accumulate in significant renal impairment, increasing bleeding risk. Thrombocytopenia adds further concern and may indicate heparin-induced thrombocytopenia depending on timing and context. The prescription should be clarified before supply. Aspirin is not a pharmacist-directed substitute for anticoagulation.

Reference: BNF