Triptan and MAOI interaction — GPhC CRA MCQ
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Correct answer: A — Do not supply sumatriptan and refer to the prescriber because moclobemide is contraindicated with triptans
Moclobemide is a monoamine oxidase A inhibitor, and triptans can have serious serotonergic and vasoconstrictive interaction risks with MAOIs. OTC sumatriptan supply would be inappropriate, and the patient should be referred for medical advice. Switching to another triptan would not solve the class concern. Propranolol is used for prevention, not acute treatment of an attack.
Reference: BNF