Morphine in renal impairment — GPhC CRA MCQ
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Correct answer: E — Withhold further routine doses and obtain urgent renal dose review
Gabapentin is renally eliminated and requires substantial dose reduction in severe renal impairment. Confusion, ataxia and myoclonus can reflect accumulation and require urgent clinical assessment and dose interruption; pregabalin also needs renal adjustment.
Reference: BNF: gabapentin: https://bnf.nice.org.uk/drugs/gabapentin/