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Acetaminophen overdose — ABEM Board MCQ

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ModerateToxicologyAcetaminophen overdoseABEM Board

A 22-year-old woman arrives as triage level 2 four hours after ingesting an unknown amount of acetaminophen. She is asymptomatic, AST is normal, and the acetaminophen level plotted on the Rumack-Matthew nomogram is above the treatment line. Which of the following is the most appropriate next step in management?

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Correct answer: EStart N-acetylcysteine

N-acetylcysteine is indicated when the timed acetaminophen concentration is above the nomogram treatment line, even before liver injury develops.

Reference: ACMT acetaminophen poisoning guidance; ABEM EM Model