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Tricyclic antidepressant overdose — ABEM Board MCQ

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EasyToxicologyTricyclic antidepressant overdoseABEM Board

A 40-year-old woman is brought as triage level 1 after an amitriptyline overdose. She is hypotensive, has a seizure, and ECG shows QRS 168 ms with terminal R wave in aVR. Which of the following is the most appropriate initial action?

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Correct answer: EIV sodium bicarbonate bolus

Tricyclic antidepressant toxicity with wide QRS, hypotension, or seizures is treated with sodium bicarbonate.

Reference: ACMT tricyclic antidepressant toxicity guidance; ABEM EM Model