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Amiodarone lung toxicity — SCE Respiratory MCQ

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HardILDAmiodarone lung toxicitySCE Respiratory

A 73-year-old man treated with amiodarone for 3 years develops cough and progressive dyspnoea. HRCT shows bilateral interstitial and organising pneumonia-like change with high-attenuation areas in the liver. FVC has fallen by 18% in 6 months. What is the most likely underlying cause?

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Correct answer: A — Amiodarone pulmonary toxicity

Chronic amiodarone exposure with interstitial change and high-attenuation liver from iodine deposition points to amiodarone pulmonary toxicity. Methotrexate and radiation pneumonitis require the corresponding exposure history. Aspirin-exacerbated respiratory disease causes asthma/rhinosinusitis rather than progressive ILD.

Reference: BNF Amiodarone; BTS ILD Guidance