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COPD diagnosis — SCE Respiratory MCQ

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HardCOPDCOPD diagnosisSCE Respiratory

A 49-year-old non-smoker has lower-lobe panacinar emphysema and mildly abnormal liver enzymes. Which investigation is most appropriate?

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Correct answer: A — Serum alpha-1 antitrypsin level with phenotype or genotype

Early or disproportionate basal panacinar emphysema and liver disease should prompt testing for alpha-1 antitrypsin deficiency. A low level should be characterised by phenotype or genotype, with family counselling and specialist assessment because acute inflammation can raise the serum concentration.

Reference: https://www.brit-thoracic.org.uk/quality-improvement/guidelines/