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Celiac disease — RCPSC IM MCQ

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ModerateGastroenterology/HepatologyCeliac diseaseRCPSC IM

A 31-year-old woman has chronic watery diarrhoea, iron deficiency, bloating, and a pruritic vesicular rash on her elbows. She has been eating gluten daily. Total IgA is normal. What is the most appropriate investigation?

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Correct answer: C — Tissue transglutaminase IgA antibody

Chronic diarrhoea, iron deficiency, and dermatitis herpetiformis suggest celiac disease. With normal total IgA and ongoing gluten intake, tTG-IgA is the appropriate initial test.

Reference: Canadian Association of Gastroenterology celiac disease guidance