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Severe eosinophilic asthma — RCPSC IM MCQ

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EasyRespirologySevere eosinophilic asthmaRCPSC IM

A 51-year-old woman with severe asthma in Edmonton uses high-dose inhaled corticosteroid-formoterol and tiotropium. She has 4 exacerbations in a year, nasal polyps, eosinophils 0.65 x 10^9/L, and FeNO 58 ppb. Spirometry confirms variable airflow obstruction and adherence is verified electronically. What is the most appropriate management?

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Correct answer: C — Refer for biologic therapy targeting type 2 inflammation

Uncontrolled severe asthma despite optimized high-dose inhaled therapy, verified adherence, eosinophilia, FeNO elevation, and nasal polyps support referral for biologic therapy targeting type 2 inflammation.

Reference: Canadian Thoracic Society severe asthma guidance