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Normal anion-gap metabolic acidosis — RCPSC IM MCQ

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HardNephrologyNormal anion-gap metabolic acidosisRCPSC IM

A 38-year-old with Sjögren syndrome has recurrent calcium-phosphate stones, potassium 2.9 mmol/L, bicarbonate 16 mmol/L, a normal anion gap and urine pH 6.7 during systemic acidosis. Which disorder best explains the findings?

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Correct answer: CDistal renal tubular acidosis with impaired urinary acidification

The best answer is “Distal renal tubular acidosis with impaired urinary acidification”. Distal RTA causes hypokalemic normal-anion-gap acidosis with persistently alkaline urine and calcium-phosphate stones, and is associated with Sjögren syndrome. Proximal RTA can acidify urine after bicarbonate depletion, type 4 RTA is hyperkalemic, diarrhea permits renal acidification and ethylene glycol raises the anion gap.

Reference: Kidney Foundation of Canada, distal renal tubular acidosis mechanism. https://kidney.ca/Research/Supported-Research/ABS/Deciphering-mechanisms-of-acid-base-balance-in-col