skip to main content

Isocyanate-induced occupational asthma — SCE Respiratory MCQ

Instant feedback + full explanation. One question, done properly.

HardOccupational Lung DiseaseIsocyanate-induced occupational asthmaSCE Respiratory

A patient with treatment-requiring, macrolide-susceptible Mycobacterium avium complex pulmonary disease has non-cavitary nodular-bronchiectatic disease, negative smears and no severe disease features. Which regimen frequency is preferred?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Intermittent azithromycin, rifampicin and ethambutol

For non-cavitary nodular-bronchiectatic, macrolide-susceptible MAC pulmonary disease without severe features, an intermittent three-drug macrolide, rifamycin and ethambutol regimen is preferred because it is effective and better tolerated. Cavitary or severe disease requires a daily regimen and often an initial aminoglycoside.

Reference: BTS NTM pulmonary disease guideline summary (Published 2017): https://www.brit-thoracic.org.uk/document-library/guidelines/ntm/bts-ntm-guideline-summary-of-recommendations/; ATS, ERS, ESCMID and IDSA NTM pulmonary disease guideline (Published 2020): https://pmc.ncbi.nlm.nih.gov/articles/PMC8375621/