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Mycobacterium avium complex pulmonary disease — SCE Respiratory MCQ

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HardTB and NTMMycobacterium avium complex pulmonary diseaseSCE Respiratory

A 43-year-old never-smoker has severe alpha-1 antitrypsin deficiency with basal panacinar emphysema. Which statement best reflects current NICE care?

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Correct answer: C — Specialist-centre referral without alpha-1-antitrypsin augmentation

NICE recommends specialist-centre referral for alpha-1 antitrypsin deficiency but does not recommend alpha-1 antitrypsin replacement therapy for COPD. Specialist care includes standard COPD treatment, smoking avoidance, liver assessment and genetic counselling or cascade testing where appropriate.

Reference: NICE NG115 recommendations for COPD (Updated 26 July 2019): https://www.nice.org.uk/guidance/ng115/chapter/Recommendations; NHS Genomics Education: alpha-1 antitrypsin deficiency (Current NHS genomics resource, accessed 30 July 2026): https://www.genomicseducation.hee.nhs.uk/genotes/knowledge-hub/alpha-1-antitrypsin-deficiency/