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Acute severe asthma — SCE Respiratory MCQ

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HardAsthmaAcute severe asthmaSCE Respiratory

A lung-transplant recipient develops a sustained FEV1 decline to 68% of the post-transplant baseline. CT shows air trapping and bronchoscopy excludes acute rejection, infection and airway stenosis. Which chronic allograft dysfunction phenotype is most likely?

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Correct answer: B — Bronchiolitis obliterans syndrome

Obstructive chronic lung-allograft dysfunction with persistent FEV1 decline and air trapping is BOS. Restrictive allograft syndrome features restriction, reduced TLC and persistent opacities. Reversible causes must be excluded before assigning CLAD.

Reference: NHS Blood and Transplant: lung transplantation. https://www.nhsbt.nhs.uk/organ-transplantation/lung/