skip to main content

Felty syndrome — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateRheumatoid arthritisFelty syndromeSCE Rheumatology

A 67-year-old man with rheumatoid arthritis, splenomegaly and recurrent leg ulcers has recurrent chest infections. Blood tests show neutrophils 0.7 × 10^9/L, haemoglobin 104 g/L, platelets 165 × 10^9/L and strongly positive rheumatoid factor. Bone marrow examination excludes haematological malignancy. What is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Felty syndrome

Felty syndrome is the triad of rheumatoid arthritis, neutropenia and splenomegaly, often in seropositive erosive disease. Large granular lymphocyte leukaemia is a key mimic, but malignancy has been excluded in the stem. Recurrent infections and leg ulcers are common clinical clues.

Reference: BSR standards for inflammatory arthritis care