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Familial Mediterranean fever — SCE Rheumatology MCQ

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ModeratePregnancy in rheumatic disease, rare conditionsFamilial Mediterranean feverSCE Rheumatology

A 22-year-old man of Turkish ancestry has recurrent self-limiting fever, pleuritic pain and monoarthritis lasting two days. CRP rises during attacks and normalises between them. His sister has renal amyloidosis. Genetic testing identifies pathogenic MEFV variants. What is the most appropriate long-term treatment?

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Correct answer: B — Colchicine

Familial Mediterranean fever presents with short attacks of fever, serositis and arthritis; colchicine reduces attacks and prevents AA amyloidosis. Methotrexate and rituximab are not first-line for FMF. Family history of amyloidosis highlights why prophylactic treatment matters.

Reference: EULAR familial Mediterranean fever recommendations