Behçet disease with ocular involvement — SCE Rheumatology MCQ

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HardVasculitisBehçet disease with ocular involvementSCE Rheumatology

A 41-year-old man has oral ulcers, genital ulcers and recurrent painful red eyes. Ophthalmology confirms posterior uveitis with retinal vasculitis; CRP is 46 mg/L and infection screening is negative. What is the most appropriate biologic?

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Correct answer: D — Infliximab

Sight-threatening Behçet uveitis and retinal vasculitis require urgent immunosuppression, and anti-TNF monoclonal therapy such as infliximab is an established option. Etanercept is not preferred for ocular Behçet disease. Delay risks irreversible visual loss, so ophthalmology and rheumatology should manage jointly.

Reference: BAD/BSR Behçet disease living guideline 2025; EULAR Behçet recommendations