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Low-titre ANA interpretation — SCE Rheumatology MCQ

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EasyMusculoskeletal investigationsLow-titre ANA interpretationSCE Rheumatology

A 30-year-old woman has fatigue and diffuse pain. ANA is 1:80 speckled, ENA and anti-dsDNA are negative, complements are normal, FBC is normal and urinalysis is negative. Examination shows no synovitis, rash or oral ulcers. What is the most appropriate interpretation?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Low-titre ANA is non-specific without compatible clinical features

Low-titre ANA is common and non-specific, particularly without objective clinical or laboratory features of connective tissue disease. Diagnosing SLE requires compatible clinical features and more specific immunology. Over-investigation risks harm and anxiety.

Reference: BSR Choosing Wisely-style rheumatology guidance; BSR SLE guideline