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Axial spondyloarthritis with uveitis — SCE Rheumatology MCQ

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HardSpondyloarthropathiesAxial spondyloarthritis with uveitisSCE Rheumatology

An adult with severe active granulomatosis with polyangiitis requires rituximab-based remission induction with glucocorticoids. Which rituximab course matches the UK SmPC?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Give 375 mg/m² intravenously once weekly for 4 doses

Explanation lettering: E = shown as B · B = shown as D · D = shown as E

E is correct. Adult GPA/MPA remission induction uses rituximab 375 mg/m² intravenously once weekly for four doses, together with glucocorticoids. The two-dose 1,000 mg regimen is the rheumatoid-arthritis course; 500 mg doses are used in maintenance strategies rather than this induction schedule. Confusing indication-specific rituximab regimens risks major under- or over-treatment.

Reference: MabThera 100 mg concentrate for infusion SmPC: https://www.medicines.org.uk/emc/product/3801/smpc