skip to main content

Anti-Ro positive SLE pregnancy — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

HardConnective tissue diseasesAnti-Ro positive SLE pregnancySCE Rheumatology

A 31-year-old woman with SLE wishes to conceive. She takes hydroxychloroquine and azathioprine, has quiescent disease for 10 months and positive anti-Ro antibodies. Renal function and urine protein are normal. What is the most important complication to screen for during pregnancy?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Fetal congenital heart block

Anti-Ro/SSA antibodies are associated with neonatal lupus and congenital heart block, so specialist obstetric surveillance is required. Hydroxychloroquine is generally continued in pregnancy and may reduce lupus activity. Azathioprine is among the immunosuppressants commonly used when clinically needed in pregnancy.

Reference: BSR pregnancy and breastfeeding guideline 2022; EULAR women's health recommendations