skip to main content

Pneumocystis prophylaxis — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateRheumatological pharmacologyPneumocystis prophylaxisSCE Rheumatology

A 64-year-old man is treated with cyclophosphamide and prednisolone 60 mg daily for severe ANCA-associated vasculitis. Lymphocytes are low and he has no sulfonamide allergy. What additional prophylaxis is most appropriate?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Co-trimoxazole for Pneumocystis jirovecii pneumonia prevention

High-dose glucocorticoids combined with cyclophosphamide place patients at risk of Pneumocystis jirovecii pneumonia, so co-trimoxazole prophylaxis is commonly used unless contraindicated. Antiviral, antifungal or TB prophylaxis should be risk-based rather than automatic. The need for prophylaxis should be reviewed with renal function and blood counts.

Reference: BSR ANCA-associated vasculitis recommendations 2025; BNF