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Mycosis fungoides — SCE Dermatology MCQ

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HardDermatopathologyMycosis fungoidesSCE Dermatology

A patient with longstanding patch-stage mycosis fungoides develops rapidly enlarging tumours. Biopsy shows sheets of CD30-positive large cells comprising more than 25% of the infiltrate. What has occurred?

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Correct answer: C — Large-cell transformation of mycosis fungoides

Large-cell transformation is defined by large cells comprising at least 25% of the infiltrate or forming microscopic nodules in established mycosis fungoides. It commonly presents with new tumours and has prognostic and treatment implications; CD30 expression may provide a therapeutic target.

Reference: https://academic.oup.com/bjd/article/180/3/496/6749857