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Epidermolysis bullosa simplex — SCE Dermatology MCQ

Instant feedback + full explanation. One question, done properly.

HardPaediatric and geneticsEpidermolysis bullosa simplexSCE Dermatology

A patient has friction-induced blistering confined mainly to palms and soles since childhood, worse with heat and sweating, with later plantar hyperkeratosis but no scarring. Which EB subtype best fits?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Localised epidermolysis bullosa simplex (formerly Weber-Cockayne type)

Explanation lettering: D = shown as A · E = shown as B · B = shown as C · A = shown as D · C = shown as E

E is correct. Localised EBS is usually limited to hands and feet, may begin from childhood to adulthood, worsens with heat and friction, and can produce palmoplantar hyperkeratosis later. Intermediate and severe EBS present earlier and more widely; mottled-pigmentation EBS develops a characteristic pigmentary phenotype, while dystrophic EB heals with scarring.

Reference: DEBRA UK: epidermolysis bullosa simplex: https://www.debra.org.uk/get-support/eb-support-and-resources/about-eb-debra-uk/epidermolysis-bullosa-simplex/