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Gianotti-Crosti syndrome — SCE Dermatology MCQ

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HardPaediatric and geneticsGianotti-Crosti syndromeSCE Dermatology

A 4-year-old develops symmetrical monomorphic papules on the cheeks, buttocks and extensor limbs after vaccination; the trunk and mucosa are relatively spared. Which feature would most strongly favour an alternative diagnosis to Gianotti-Crosti syndrome?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Palmoplantar vesicles accompanied by painful oral erosions

Explanation lettering: C = shown as A · E = shown as C · A = shown as E

D is correct. Painful oral erosions with palmoplantar vesicles point to hand, foot and mouth disease rather than Gianotti-Crosti. Gianotti-Crosti is a monomorphic, symmetric acral and facial papular eruption with buttock involvement, relative truncal sparing and a benign course over weeks, often after infection or immunisation.

Reference: PCDS: Gianotti-Crosti syndrome: https://www.pcds.org.uk/clinical-guidance/gianotti-crosti-syndrome-syn-papular-acrodermatitis-of-childhood